TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

Dixon, KO; Tabaka, M; Schramm, MA; Xiao, S; Tang, RH; Dionne, D; Anderson, AC; Rozenblatt-Rosen, O; Regev, A; Kuchroo, VK

Kuchroo, VK (corresponding author), Harvard Med Sch, Brigham & Womens Hosp, Evergrande Ctr Immunol Dis, Boston, MA 02115 USA.; Kuchroo, VK (corresponding author), Harvard Med Sch, Brigham & Womens Hosp, Ann Romney Ctr Neurol Dis, Boston, MA 02115 USA.; Kuchroo, VK (corresponding author), Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.

NATURE, 2021; 595 (7865): 101

Abstract

T cell immunoglobulin and mucin-containing molecule 3 (TIM-3), first identified as a molecule expressed on interferon-gamma producing T cells(1), is e......

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