ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis

Zhang, YX; Zhang, JW; Zhao, Y; Zhang, YQ; Liu, L; Xu, XF; Wang, XZ; Fu, JL

Wang, XZ; Fu, JL (通讯作者)，Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Dept Neurol, 600 Yishan Rd, Shanghai 200233, Peoples R China.

CELL DEATH & DISEASE, 2023; 14 (11):

Abstract

Neuroinflammation plays critical roles in vascular dementia (VaD), the second leading cause of dementia, which can be induced by chronic cerebral hypo......

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