Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR(L858R/T790M/C797S)

Li, QN; Zhang, T; Li, SL; Tong, LJ; Li, JY; Su, ZC; Feng, F; Sun, DH; Tong, Y; Wang, X; Zhao, ZJ; Zhu, LL; Ding, J; Li, HL; Xie, H; Xu, YF

Li, HL; Xu, YF (reprint author), East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China.; Xie, H (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab

ACS MEDICINAL CHEMISTRY LETTERS, 2019; 10 (6): 869

Abstract

In this paper, we describe the discovery and optimization of a series of noncovalent reversible epidermal growth factor receptor inhibitors of EGFR(L8......

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