HHEX promotes myeloid transformation in cooperation with mutant ASXL1

Takeda, R; Asada, S; Park, SJ; Yokoyama, A; Becker, HJ; Kanai, A; Visconte, V; Hershberger, C; Hayashi, Y; Yonezawa, T; Tamura, M; Fukushima, T; Tanaka, Y; Fukuyama, T; Matsumoto, A; Yamasaki, S; Nakai, K; Yamazaki, S; Inaba, T; Shibata, T; Inoue, D; Honda, H; Goyama, S; Maciejewski, JP; Kitamura, T

Asada, S (corresponding author), Tokyo Womens Med Univ, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan.; Kitamura, T (corresponding author), Univ Tokyo, Inst Med Sci, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan.

BLOOD, 2020; 136 (14): 1670

Abstract

Additional sex combs-like 1 (ASXL1), an epigenetic modulator, is frequently mutated in myeloid neoplasms. Recent analyses of mutant ASXL1 conditional ......

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