PCA-based GRS analysis enhances the effectiveness for genetic correlation detection

Zhao, Y; Ning, YJ; Zhang, F; Ding, M; Wen, Y; Shi, L; Wang, KP; Lu, MN; Sun, JY; Wu, ML; Cheng, BL; Ma, M; Zhang, L; Cheng, SQ; Shen, H; Tian, Q; Guo, X; Deng, HW

Zhang, F (reprint author), Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, Key Lab Trace Elements & Endem Dis Natl Hlth Comm, Xian, Peoples R China.; Deng, HW (reprint author), Tulane Univ, Ctr Bioinformat & Genom, Dept Global Biostat & Data Sci, Sch P

BRIEFINGS IN BIOINFORMATICS, 2019; 20 (6): 2291

Abstract

Genetic risk score (GRS, also known as polygenic risk score) analysis is an increasingly popular method for exploring genetic architectures and relati......

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