An optimized protocol for the generation and monitoring of conditional orthotopic lung cancer in the KP mouse model using an adeno-associated virus vector compatible with biosafety level 1

Deng, HB; Ge, HX; Dubey, C; Losmanova, T; Medová, M; Konstantinidou, G; Mutlu, SM; Birrer, FE; Brodie, TM; Stroka, D; Wang, WX; Peng, RW; Dorn, P; Marti, TM

Peng, RW; Dorn, P; Marti, TM (通讯作者),Univ Bern, Bern Univ Hosp, Dept Gen Thorac Surg, Inselspital, Murtenstra 28, CH-3008 Bern, Switzerland.;Peng, RW; Dorn, P; Marti, TM (通讯作者),Univ Bern, Dept Biomed Res, Bern, Switzerland.

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2023; ():

Abstract

BackgroundThe inducible Kras/p53 lung adenocarcinoma mouse model, which faithfully recapitulates human disease, is routinely initiated by the intratra......

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