CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression

Spencer, DH; Russler-Germain, DA; Ketkar, S; Helton, NM; Lamprecht, TL; Fulton, RS; Fronick, CC; O'Laughlin, M; Heath, SE; Shinawi, M; Westervelt, P; Payton, JE; Wartman, LD; Welch, JS; Wilson, RK; Walter, MJ; Link, DC; DiPersio, JF; Ley, TJ

Ley, TJ (reprint author), Washington Univ, Sch Med, Dept Med, Sect Stem Cell Biol,Div Oncol, St Louis, MO 63110 USA.; Ley, TJ (reprint author), Washington Univ, McDonnell Genome Inst, St Louis, MO 63110 USA.

CELL, 2017; 168 (5): 801

Abstract

DNMT3A mutations occur in similar to 25% of acute myeloid leukemia (AML) patients. The most common mutation, DNMT3A R882H, has dominant negative activ......

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