Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Tian, RL; Abarientos, A; Hong, JS; Hashemi, SH; Yan, R; Drager, N; Leng, K; Nalls, MA; Singleton, AB; Xu, K; Faghri, F; Kampmann, M

Tian, RL; Kampmann, M (corresponding author), Univ Calif San Francisco, Dept Biochem & Biophys, Inst Neurodegenerat Dis, San Francisco, CA 94143 USA.; Tian, RL (corresponding author), Univ Calif San Francisco, Biophys Grad Program, San Francisco, CA 94143 USA.; Kampmann, M (corresponding author), Chan Zuckerberg Biohub, San Francisco, CA 94158 USA.; Tian, RL (corresponding author), Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China.

NATURE NEUROSCIENCE, 2021; 24 (7): 1020

Abstract

Single-cell transcriptomics provide a systematic map of gene expression in different human cell types. The next challenge is to systematically underst......

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