Bridging immunogenicity assays for IgG4 therapeutics: mitigating interference from Fc-Fc interactions

Partridge, MA; Vijayam, U; Karayusuf, EK; Shum, E; Sirimanne, T; Garlits, J; Chen, JH; Torri, A; Sumner, G

Partridge, MA (reprint author), Regeneron Pharmaceut Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA.

BIOANALYSIS, 2017; 9 (9): 707

Abstract

Aim: A bridging immunogenicity assay for a human IgG4 mAb therapeutic was transferred to an automation system to increase throughput. However, backgro......

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