Improving fine-mapping by modeling infinitesimal effects

Cui, R; Elzur, RA; Kanai, M; Ulirsch, JC; Weissbrod, O; Daly, MJ; Neale, BM; Fan, Z; Finucane, HK

Cui, R; Finucane, HK (通讯作者)，Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA.;Cui, R; Finucane, HK (通讯作者)，Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Cui, R; Finucane, HK (通讯作者)，Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA.;Cui, R (通讯作者)，Broad Inst MIT & Harvard, Novo Nordisk Fdn Ctr Genom Mech Dis, Cambridge, MA 02142 USA.;Fan, Z (通讯作者)，Yale Univ, Dept Stat & Data Sci, New Haven, CT 06520 USA.

NATURE GENETICS, 2023; 55 (12):

Abstract

Fine-mapping aims to identify causal genetic variants for phenotypes. Bayesian fine-mapping algorithms (for example, SuSiE, FINEMAP, ABF and COJO-ABF)......

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