Delta- and beta-secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease

Xia, YY; Wang, ZH; Zhang, ZT; Liu, X; Yu, SP; Wang, JZ; Wang, XC; Ye, KQ

Ye, KQ (corresponding author), Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA.; Wang, XC (corresponding author), Huazhong Univ Sci & Technol, Dept Pathophysiol, Tongji Med Coll, Key Lab,Minist Educ Neurol Dis, Wuhan 430033, Peoples R China.

PROGRESS IN NEUROBIOLOGY, 2021; 204 ():

Abstract

Asparagine endopeptidase (AEP), a newly identified delta-secretase, simultaneously cleaves both APP and Tau, promoting Alzheimer's disease (AD) pathol......

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