From ROR gamma t Agonist to Two Types of ROR gamma t Inverse Agonists

Wang, YH; Cai, W; Tang, T; Liu, Q; Yang, T; Yang, LQ; Ma, YL; Zhang, GF; Huang, YF; Song, XX; Orband-Miller, LA; Wu, QQ; Zhou, L; Xiang, ZJ; Xiang, JN; Leung, S; Shao, LM; Lin, XC; Lobera, M; Ren, F

Wang, YH (reprint author), Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China.; Ren, F (reprint author), GlaxoSmithKline, Res & Dev, 3 Bldg,898 Halei Rd, Shanghai 201203, Peoples R China.

ACS MEDICINAL CHEMISTRY LETTERS, 2018; 9 (2): 120

Abstract

Biaryl amides as new ROR gamma t modulators were discovered. The crystal structure of biaryl amide agonist 6 in complex with ROR gamma t ligand bindin......

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