NUMB enhances Notch signaling by repressing ubiquitination of NOTCH1 intracellular domain

Luo, ZY; Mu, LL; Zheng, Y; Shen, WC; Li, JL; Xu, LC; Zhong, B; Liu, Y; Zhou, Y

Liu, Y; Zhou, Y (corresponding author), Wuhan Univ, Sch Med, Renmin Hosp, Med Res Inst,Coll Life Sci, Wuhan 430072, Peoples R China.

JOURNAL OF MOLECULAR CELL BIOLOGY, 2020; 12 (5): 345

Abstract

The release and nuclear translocation of the intracellular domain of Notch receptor (NICD) is the prerequisite for Notch signalingmediated transcripti......

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