Pegylated arginine deiminase depletes plasma arginine but maintains tissue arginine availability in young pigs

Mohammad, MA; Didelija, IC; Stoll, B; Nguyen, TC; Marini, JC

Marini, JC (corresponding author), Baylor Coll Med, USDA, Childrens Nutr Res Ctr, ARS, Houston, TX 77030 USA.; Marini, JC (corresponding author), Baylor Coll Med, Dept Pediat, Pediat Crit Care Med, Houston, TX 77030 USA.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2021; 320 (3): E641

Abstract

Pegylated arginine deiminase (ADI-PEG20) results in the depletion of arginine with the production of isomolar amounts of citrul-line. This citrulline ......

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