Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle

Feng, J; Zhao, YH; Xie, ZL; Zang, KK; Sviben, S; Hu, XM; Fitzpatrick, JAJ; Wen, L; Liu, YF; Wang, T; Lawson, K; Liu, Q; Yan, Y; Dong, XZ; Han, L; Wu, GF; Kim, BS; Hu, HZ

Feng, J; Hu, HZ (通讯作者),Washington Univ, Ctr Study Itch & Sensory Disorders, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA.;Feng, J (通讯作者),Chinese Acad Sci, Ctr Neurol & Psychiat Res & Drug Discovery, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China.

SCIENCE TRANSLATIONAL MEDICINE, 2022; 14 (653):

Abstract

Itch sensation provokes the scratch reflex to protect us from harmful stimuli in the skin. Although scratching transiently relieves acute itch through......

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