Flexizyme-Enabled Benchtop Biosynthesis of Thiopeptides

Fleming, SR; Bartges, TE; Vinogradov, AA; Kirkpatrick, CL; Goto, Y; Suga, H; Hicks, LM; Bowers, AA

Bowers, AA (reprint author), Univ N Carolina, Div Chem Biol & Med Chem, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USA.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019; 141 (2): 758

Abstract

Thiopeptides are natural antibiotics that are fashioned from short peptides by multiple layers of post-translational modification. Their biosynthesis,......

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