SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR

Cui, S; Hu, HJ; Chen, A; Cui, M; Pan, XJ; Zhang, PF; Wang, GJ; Wang, H; Hao, HP

Wang, H; Hao, HP (通讯作者),China Pharmaceut Univ, State Key Lab Nat Med, Key Lab Drug Metab & Pharmacokinet, Nanjing 210009, Peoples R China.

ACTA PHARMACEUTICA SINICA B, 2023; 13 (2): 559

Abstract

Farnesoid X receptor (FXR) is widely accepted as a promising target for various liver diseases; however, panels of ligands in drug development show li......

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