Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro

Salpini, R; Surdo, M; Warner, N; Cortese, MF; Colledge, D; Soppe, S; Bellocchi, MC; Armenia, D; Carioti, L; Continenza, F; Di Carlo, D; Saccomandi, P; Mirabelli, C; Pollicita, M; Longo, R; Romano, S; Cappiello, G; Spano, A; Trimoulet, P; Fleury, H; V

Svicher, V (reprint author), Tor Vergata Univ Hosp, Hepatol Unit, Rome, Italy.; Perno, CF (reprint author), Univ Duisburg Essen, Inst Virol, Univ Hosp, Essen, Germany.

ONCOTARGET, 2017; 8 (9): 15704

Abstract

Background: An impaired HBsAg-secretion can increase HBV oncogenic-properties. Here, we investigate genetic-determinants in HBsAg correlated with HBV-......

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