High gamma-glutamyl hydrolase and low folylpolyglutamate synthetase expression as prognostic biomarkers in patients with locally advanced gastric cancer who were administrated postoperative adjuvant chemotherapy with S-1

Maezawa, Y; Sakamaki, K; Oue, N; Kimura, Y; Hashimoto, I; Hara, K; Kano, K; Aoyama, T; Hiroshima, Y; Yamada, T; Yamamoto, N; Ogata, T; Ito, H; Cho, H; Shiozawa, M; Yoshikawa, T; Morinaga, S; Rino, Y; Yasui, W; Masuda, M; Miyagi, Y; Oshima, T

Oshima, T (reprint author), Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Yokohama, Kanagawa 2418515, Japan.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2020; 146 (1): 75

Abstract

Purpose The enzymes gamma-glutamyl hydrolase (GGH) and folylpolyglutamate synthetase (FPGS) regulate intracellular folate concentrations needed for ce......

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