DNA Polymerase theta Increases Mutational Rates in Mitochondrial DNA

Wisnovsky, S; Sack, T; Pagliarini, DJ; Laposa, RR; Kelley, SO

Kelley, SO (reprint author), Univ Toronto, Dept Biochem, Toronto, ON, Canada.; Laposa, RR (reprint author), Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.; Kelley, SO (reprint author), Univ Toronto, Dept Pharmaceut Sci, Toronto, ON, Canada.

ACS CHEMICAL BIOLOGY, 2018; 13 (4): 900

Abstract

Replication and maintenance of mitochondrial DNA (mtDNA) is essential for cellular function, yet few DNA polymerases are known to function in mitochon......

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