Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits

Henry, RJ; Ritzel, RM; Barrett, JP; Doran, SJ; Jiao, Y; Leach, JB; Szeto, GL; Wu, JF; Stoica, BA; Faden, AI; Loane, DJ

Henry, RJ; Loane, DJ (corresponding author), Univ Maryland, Sch Med, Dept Anesthesiol, Baltimore, MD 21201 USA.; Henry, RJ; Loane, DJ (corresponding author), Univ Maryland, Sch Med, Shock Trauma & Anesthesiol Res STAR Ctr, Baltimore, MD 21201 USA.; Loane, DJ (corresponding author), Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, Dublin, Ireland.

JOURNAL OF NEUROSCIENCE, 2020; 40 (14): 2960

Abstract

Chronic neuroinflammation with sustained microglial activation occurs following severe traumatic brain injury (TBI) and is believed to contribute to s......

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