CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker

Mishra, AK; Shahid, S; Karade, SS; Agnihotri, P; Kolesnikov, A; Hasan, SS; Mariuzza, RA

Mariuzza, RA (通讯作者)，Univ Maryland, Inst Biosci & Biotechnol Res, WM Keck Lab Struct Biol, Rockville, MD 20850 USA.;Mariuzza, RA (通讯作者)，Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA.

STRUCTURE, 2023; 31 (10):

Abstract

Lymphocyte activation gene 3 protein (LAG3) is an inhibitory receptor that is upregulated on exhausted T cells in tumors. LAG3 is a major target for c......

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