Dimeric Fc gamma R ectodomains detect pathogenic anti-platelet factor 4-heparin antibodies in heparin-induced thromobocytopenia

Wines, BD; Tan, CW; Duncan, E; McRae, S; Baker, RI; Andrews, RK; Esparon, S; Gardiner, EE; Hogarth, PM

Hogarth, PM (reprint author), Burnet Inst, Immune Therapies Grp, 85 Commercial Rd, Melbourne, Vic 3004, Australia.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2018; 16 (12): 2520

Abstract

Background Heparin-induced thrombocytopenia (HIT) is a major and potentially fatal consequence of antibodies produced against platelet factor 4 (PF4)-......

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