Discovery of novel potent PI3K/mTOR dual-target inhibitors based on scaffold hopping: Design, synthesis, and antiproliferative activity

Yang, Y; Sun, X; Luo, LX; Peng, RJ; Yang, RQ; Cheng, ZJ; Lv, Y; Li, HF; Tang, QD; Zhu, WF; Qiao, D; Xu, S

Zhu, WF; Qiao, D; Xu, S (通讯作者)，Jiangxi Sci & Technol Normal Univ, Sch Pharm, Jiangxi Prov Key Lab Drug Design & Evaluat, 605 Fenglin Rd, Nanchang 330013, Jiangxi, Peoples R China.

ARCHIV DER PHARMAZIE, 2023; 356 (12):

Abstract

The PI3K/AKT/mTOR pathway is one of the most common dysregulated signaling cascade responses in human cancers, playing a crucial role in cell prolifer......

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