Rational Regulation of Reaction Specificity of Nitrilase for Efficient Biosynthesis of 2-Chloronicotinic Acid through a Single Site Mutation

Dai, AD; Tang, XL; Wu, ZM; Tang, JT; Zheng, RC; Zheng, YG

Zheng, RC (通讯作者)，Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Key Lab Bioorgan Synth Zhejiang Prov, Hangzhou, Peoples R China.;Zheng, RC (通讯作者)，Zhejiang Univ Technol, Engn Res Ctr Bioconvers & Biopurificat, Minist Educ, Hangzhou, Peoples R China.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2022; 88 (5):

Abstract

Nitrilase-catalyzed hydrolysis of 2-chloronicotinonitrile (2-CN) is a promising approach for the efficient synthesis of 2-chloronicotinic acid (2-CA).......

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