Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase

Akakpo, JY; Ramachandran, A; Duan, LQ; Schaich, MA; Jaeschke, MW; Freudenthal, BD; Ding, WX; Rumack, BH; Jaeschke, H

Jaeschke, H (reprint author), Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, 3901 Rainbow Blvd,MS 1018, Kansas City, KS 66160 USA.

TOXICOLOGICAL SCIENCES, 2019; 170 (1): 57

Abstract

Acetaminophen (APAP) overdose is the most common cause of hepatotoxicity and acute liver failure in the United States and many western countries. Howe......

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