The respiratory depressant effects of mitragynine are limited by its conversion to 7-OH mitragynine

Hill, R; Kruegel, AC; Javitch, JA; Lane, JR; Canals, M

Hill, R; Canals, M (通讯作者),Univ Nottingham, Queens Med Ctr, Sch Life Sci, Div Physiol Pharmacol & Neurosci Sch, Nottingham, England.

BRITISH JOURNAL OF PHARMACOLOGY, 2022; 179 (14): 3875

Abstract

Background and Purpose Mitragynine, the major alkaloid in Mitragyna speciosa (kratom), is a partial agonist at the mu opioid receptor. CYP3A-dependent......

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