Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment

Che, JX; Bing, SW; Lu, JL; Jin, ZG; Gao, J; Sheng, HC; Li, D; Yang, B; He, QJ; Ying, MD; Dong, XW

Ying, MD (通讯作者),Zhejiang Univ, Inst Pharmacol & Toxicol, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Peoples R China.;Dong, XW (通讯作者),Zhejiang Univ, Ctr Canc, Hangzhou 310058, Peoples R China.;Ying, MD (通讯作者),Natl Clin Res Ctr Child Hlth, Pediat Canc Res Ctr, Hangzhou 310052, Peoples R China.;Dong, XW (通讯作者),Zhejiang Univ, Hangzhou Inst Innovat Med, Inst Drug Discovery & Design, Coll Pharmaceut Sci,Innovat Inst Artificial Intel, Hangzhou 310058, Peoples R China.;Dong, XW (通讯作者),Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pharm, Hangzhou 310009, Peoples R China.

JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (19): 13530

Abstract

Patients with high-risk neuroblastoma face limited treatment choices, typically involving a combination of cytotoxic and differentiation maintenance t......

Full Text Link