High-Throughput Dual Screening Method for Ras Activities and Inhibitors

Kopra, K; van Adrichem, AJ; Salo-Ahen, OMH; Peltonen, J; Wennerberg, K; Harma, H

Kopra, K (reprint author), Univ Turku, Inst Biomed, Kiinamyllynkatu 10 C, FI-20520 Turku, Finland.; Kopra, K (reprint author), Univ Turku, Mat Chem & Chem Anal, Vatselankatu 2, FI-20014 Turku, Finland.

ANALYTICAL CHEMISTRY, 2017; 89 (8): 4508

Abstract

Ras GTPases act as "molecular switches", alternating between inactive GDP-bound and active GTP-bound conformation. Ras-oncogenes were discovered over ......

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