Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

Kim, JE; Patel, MA; Mangraviti, A; Kim, ES; Theodros, D; Velarde, E; Liu, A; Sankey, EW; Tam, A; Xu, HY; Mathios, D; Jackson, CM; Harris-Bookman, S; Garzon-Muvdi, T; Sheu, M; Martin, AM; Tyler, BM; Tran, PT; Ye, XB; Olivi, A; Taube, JM; Burger, PC; D

Lim, M (reprint author), Johns Hopkins Univ, Phipps Bldg,Room 123,600 N Wolfe St, Baltimore, MD 21287 USA.

CLINICAL CANCER RESEARCH, 2017; 23 (1): 124

Abstract

Purpose: Checkpoint molecules like programmed death-1 (PD-1) and T-cell immunoglobulin mucin-3 (TIM-3) are negative immune regulators that may be upre......

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