Single AAV-Mediated CRISPR-SaCas9 Inhibits HSV-1 Replication by Editing ICP4 in Trigeminal Ganglion Neurons

Chen, YX; Zhi, SY; Liang, PP; Zheng, Q; Liu, MN; Zhao, Q; Ren, J; Cui, J; Huang, JJ; Liu, YZ; Zhou, SY

Huang, JJ; Liu, YZ; Zhou, SY (corresponding author), Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Peoples R China.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2020; 18 (): 33

Abstract

Herpes simplex keratitis (HSK) is the most common cause of corneal blindness in developed nations, caused by primary or recurrent herpes simplex virus......

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