Discovery of Thieno[2,3-d]pyrimidine-based KRAS G 12D inhibitors as potential anticancer agents via combinatorial virtual screening

Li, L; Liu, J; Yang, ZC; Zhao, HT; Deng, BL; Ren, YC; Mai, RY; Huang, JL; Chen, JJ

Chen, JJ (通讯作者)，Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022; 233 ():

Abstract

A series of novel thieno[2,3-d]pyrimidine analogs were designed and synthesized as KRAS G12D inhibitors via combinatorial virtual screening approach. ......

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