TanK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation

Hu, YW; Zhang, J; Wu, XM; Cao, L; Nie, P; Chang, MX

Chang, MX (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Hubei, Peoples R China.; Chang, MX (reprint author), Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Hubei, Peoples R China.

FRONTIERS IN IMMUNOLOGY, 2018; 9 ():

Abstract

TANK-binding kinase 1 (TBK1) is an important serine/threonine-protein kinase that mediates phosphorylation and nuclear translocation of IRF3, which co......

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