FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation

Zhu, RQ; Li, L; Nguyen, B; Seo, J; Wu, M; Seale, T; Levis, M; Duffield, A; Hu, Y; Small, D

Small, D (corresponding author), Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA.; Hu, Y (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Peoples R China.; Small, D (corresponding author), Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA.

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021; 6 (1):

Abstract

Tyrosine kinase inhibitors (TKIs) targeting FLT3 have shown activity but when used alone have achieved limited success in clinical trials, suggesting ......

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