Discovery of Reversible Covalent Bruton's Tyrosine Kinase InhibitorsPRN473 and PRN1008 (Rilzabrutinib)

Owens, TD; Brameld, KA; Verner, EJ; Ton, T; Li, XY; Zhu, J; Masjedizadeh, MR; Bradshaw, JM; Hill, RJ; Tam, D; Bisconte, A; Kim, EO; Francesco, M; Xing, Y; Shu, J; Karr, D; LaStant, J; Finkle, D; Loewenstein, N; Haberstock-Debic, H; Taylor, MJ; Nunn, P; Langrish, CL; Goldstein, DM

Owens, TD (通讯作者)，Principia Biopharma, San Francisco, CA 94080 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2022; 65 (7): 5300

Abstract

Bruton's tyrosine kinase (BTK), a Tec family tyrosine kinase, is critical in immune pathways as an essentialintracellular signaling element, participa......

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