Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

Ogden, TEH; Yang, JC; Schimpl, M; Easton, LE; Underwood, E; Rawlins, PB; McCauley, MM; Langelier, MF; Pascal, JM; Embrey, KJ; Neuhaus, D

Neuhaus, D (corresponding author), MRC, Lab Mol Biol, Francis Crick Ave, Cambridge CB2 0QH, England.

NUCLEIC ACIDS RESEARCH, 2021; 49 (4): 2266

Abstract

PARP-1 is a key early responder to DNA damage in eukaryotic cells. An allosteric mechanism links initial sensing of DNA single-strand breaks by PARP-1......

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