Exceptionally high-affinity Ras binders that remodel its effector domain

McGee, JH; Shim, SY; Lee, SJ; Swanson, PK; Jiang, SY; Durney, MA; Verdine, GL

Verdine, GL (reprint author), Harvard Univ, 12 Oxford St, Cambridge, MA 02138 USA.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018; 293 (9): 3265

Abstract

The Ras proteins are aberrantly activated in a wide range of human cancers, often endowing tumors with aggressive properties and resistance to therapy......

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