Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5

Clement-Lacroix, P; Little, CB; Smith, MM; Cottereaux, C; Merciris, D; Meurisse, S; Mollat, P; Touitou, R; Brebion, F; Gosmini, R; De Ceuninck, F; Botez, I; Lepescheux, L; van der Aar, E; Christophe, T; Vandervoort, N; Blanque, R; Comas, D; Deprez, P; Amantini, D

Clement-Lacroix, P (通讯作者)，102 Ave Gaston Roussel, F-93230 Romainville, France.

OSTEOARTHRITIS AND CARTILAGE, 2022; 30 (2): 291

Abstract

Objective: A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a key enzyme in degradation of cartilage in osteoarthritis (O......

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