Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients

Valdez, C; Wong, YC; Schwake, M; Bu, GJ; Wszolek, ZK; Krainc, D

Krainc, D (reprint author), Northwestern Univ, Feinberg Sch Med, Ken & Ruth Davee Dept Neurol, 303 E Chicago Ave,Ward 12-140, Chicago, IL 60611 USA.

HUMAN MOLECULAR GENETICS, 2017; 26 (24): 4861

Abstract

Frontotemporal dementia (FTD) encompasses a group of neurodegenerative disorders characterized by cognitive and behavioral impairments. Heterozygous m......

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