Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells

Rashidian, M; Ingram, JR; Dougan, M; Dongre, A; Whang, KA; LeGall, C; Cragnolini, JJ; Bierie, B; Gostissa, M; Gorman, J; Grotenbreg, GM; Bhan, A; Weinberg, RA; Ploegh, HL

Ploegh, HL (reprint author), Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA.; Ploegh, HL (reprint author), MIT, Dept Biol, Cambridge, MA 02139 USA.

JOURNAL OF EXPERIMENTAL MEDICINE, 2017; 214 (8): 2243

Abstract

Immunotherapy using checkpoint-blocking antibodies against targets such as CTLA-4 and PD-1 can cure melanoma and non-small cell lung cancer in a subse......

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