Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs?

Schmidt, C; Babu, T; Kostrhunova, H; Timm, A; Basu, U; Ott, I; Gandin, V; Brabec, V; Gibson, D

Gibson, D (corresponding author), Hebrew Univ Jerusalem, Sch Pharm, Inst Drug Res, IL-91120 Jerusalem, Israel.; Brabec, V (corresponding author), Czech Acad Sci, Inst Biophys, Brno 61265, Czech Republic.; Ott, I (corresponding author), Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, D-38106 Braunschweig, Germany.; Gandin, V (corresponding author), Univ Padua, Dipartimento Sci Farmaco, I-35131 Padua, Italy.; Brabec, V (corresponding author), Palacky Univ Olomouc, Fac Sci, De

JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (15): 11364

Abstract

Multi-action" Pt(IV) derivatives of cisplatin with combretastatin A4 (CA4) bioactive ligands that are conjugated to Pt(IV) by carbonate are unique bec......

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