A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia

Sellmer, A; Pilsl, B; Beyer, M; Pongratz, H; Wirth, L; Elz, S; Dove, S; Henninger, SJ; Spiekermann, K; Polzer, H; Klaeger, S; Kuster, B; Bohmer, FD; Fiebig, HH; Kramer, OH; Mahboobi, S

Mahboobi, S (corresponding author), Univ Regensburg, Fac Chem & Pharm, Inst Pharm, D-93040 Regensburg, Germany.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020; 193 ():

Abstract

Mutants of the FLT3 receptor tyrosine kinase (RTK) with duplications in the juxtamembrane domain (FLT3-ITD) act as drivers of acute myeloid leukemia (......

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