Epitope Mapping for a Preclinical Bevacizumab (Avastin) Biosimilar on an Extended Construct of Vascular Endothelial Growth Factor A Using Millisecond Hydrogen-Deuterium Exchange Mass Spectrometry

Brown, KA; Lento, C; Rajendran, S; Dowd, J; Wilson, DJ

Wilson, DJ (corresponding author), York Univ, Chem Dept, Toronto, ON M3J 1P3, Canada.; Wilson, DJ (corresponding author), York Univ, Ctr Res Mass Spectrometry, Toronto, ON M3J 1P3, Canada.

BIOCHEMISTRY, 2020; 59 (30): 2776

Abstract

The success of bevacizumab (Avastin), a monoclonal antibody (mAb) anticancer drug targeting vascular endothelial growth factor A (VEGF-A), has motivat......

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