Renal Klotho safeguards platelet lifespan in advanced chronic kidney disease through restraining Bcl-xL ubiquitination and degradation

Lan, QG; Du, CH; Xiong, JC; Wu, YD; Liao, WN; Liu, CN; Chen, J; Ran, L; Wang, Y; Wang, YQ; Wang, JP; Zhao, JH; Yang, K

Zhao, JH; Yang, K (通讯作者),Army Med Univ, Xinqiao Hosp, Dept Nephrol, 183 Xinqiao St, Chongqing 400037, Peoples R China.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2022; 20 (12): 2972

Abstract

Background Thrombosis and hemorrhage as two opposite pathologies are prevalent within the chronic kidney disease (CKD) population. Platelet homeostasi......

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