Design, Synthesis, and in Vitro Biological Evaluation of 14-Hydroxytylophorine-dichloroacetate Co-drugs as Antiproliferative Agents

Omran, Z; Alarja, M; Abdalla, AN; Ibrahim, MM; Hossain, MA; Chen, LW; Liu, YX; Wang, QM

Omran, Z (reprint author), Umm Al Qura Univ, Coll Pharm, Al Abidiyya 21955, Makkah, Saudi Arabia.

CHEMICAL & PHARMACEUTICAL BULLETIN, 2019; 67 (11): 1208

Abstract

Co-drug, or mutual-prodrug, is a drug design approach consisting of covalently linking two active drugs so as to improve the pharmacokinetics and/or p......

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