PHD3 inhibits colon cancer cell metastasis through the occludin-p38 pathway

Li, YY; Yuan, TL; Zhang, HW; Liu, ST; Lun, J; Guo, J; Wang, Y; Zhang, YY; Fang, J

Fang, J (通讯作者)，Qingdao Univ, Sch Basic Med, Affiliated Hosp, Dept Oncol,Qingdao Canc Inst, Qingdao 266071, Peoples R China.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2023; 55 (11): 1749

Abstract

Prolyl hydroxylase 3 (PHD3) hydroxylates HIFa in the presence of oxygen, leading to HIFa degradation. PHD3 inhibits tumorigenesis. However, the underl......

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