Anti-alpha(4)beta(7) monoclonal antibody-conjugated nanoparticles block integrin alpha(4)beta(7) on intravaginal T cells in rhesus macaques

Yang, SD; Arrode-Bruses, G; Frank, I; Grasperge, B; Blanchard, J; Gettie, A; Martinelli, E; Ho, EA

Ho, EA (corresponding author), Univ Waterloo, Sch Pharm, 10 Victoria St SA, Kitchener, ON N2G 1C5, Canada.; Martinelli, E (corresponding author), Populat Council, Ctr Biomed Res, One Dag Hammarskjold Plaza, New York, NY 10017 USA.

SCIENCE ADVANCES, 2020; 6 (34):

Abstract

Intravenous administration of anti-alpha(4)beta(7) monoclonal antibody in macaques decreases simian immunodeficiency virus (SIV) vaginal infection and......

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