Selection and early clinical evaluation of the brain-penetrant 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor UE2343 (Xanamem (TM))

Webster, SP; McBride, A; Binnie, M; Sooy, K; Seckl, JR; Andrew, R; Pallin, TD; Hunt, HJ; Perrior, TR; Ruffles, VS; Ketelbey, JW; Boyd, A; Walker, BR

Webster, SP (reprint author), Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.

BRITISH JOURNAL OF PHARMACOLOGY, 2017; 174 (5): 396

Abstract

BACKGROUND AND PURPOSE Reducing glucocorticoid exposure in the brain via intracellular inhibition of the cortisol-regenerating enzyme 11 beta-hydroxys......

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