A Molecular Switch between Mammalian MLL Complexes Dictates Response to Menin-MLL Inhibition

Soto-Feliciano, YM; Sánchez-Rivera, FJ; Perner, F; Barrows, DW; Kastenhuber, ER; Ho, YJ; Carroll, T; Xiong, YJ; Anand, D; Soshnev, AA; Gates, L; Beytagh, MC; Cheon, D; Gu, SQ; Liu, XS; Krivtsov, A; Meneses, M; de Stanchina, E; Stone, RM; Armstrong, SA; Lowe, SW; Allis, CD

Allis, CD (通讯作者)，Rockefeller Univ, Allis Lab, Box 78,1230 York Ave, New York, NY 10065 USA.;Lowe, SW (通讯作者)，Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Canc Biol & Genet Program, New York, NY 10065 USA.;Armstrong, SA (通讯作者)，Harvard Med Sch, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA.

CANCER DISCOVERY, 2023; 13 (1): 146

Abstract

Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment......

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