Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model

Bednar, KJ; Shanina, E; Ballet, R; Connors, EP; Duan, ST; Juan, J; Arlian, BM; Kulis, MD; Butcher, EC; Fung-Leung, WP; Rao, TS; Paulson, JC; Macauley, MS

Macauley, MS (reprint author), Univ Alberta, Gunning Lemieux Chem Ctr E5 8A, 11227 Saskatchewan Dr NW, Edmonton, AB T6G 2G2, Canada.; Paulson, JC (reprint author), Scripps Res Inst, 10550 North Torrey Pines Rd,MB-202, La Jolla, CA 92037 USA.

JOURNAL OF IMMUNOLOGY, 2017; 199 (9): 3116

Abstract

CD22, a sialic acid-binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health and disease......

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